Animal studies with rats have shown that cerium dioxide nanoparticles deposit in the lung after inhalation but do not reach the brain. Typically, the blood-brain-barrier is impermeable to nanoparticles which only pass this barrier when precisely targeted with specific surface coatings.

 

Cerium dioxide nanoparticles can not reach the brain after inhalation of these particles [1]. This result has been confirmed in two independent studies which have been carried out in the USA with two different variants of CeO2[2, 3]. Very small particles (5 nm) and larger ones (30 nm) have been used to inject rats with relatively high doses to investigate the distribution within the organism. Neither the small particles nor the larger ones could be found in the brain. As described by many other studies most of the applied particles could be found in the liver, the spleen and the kidneys.

(please compare „body barriers – Nanoparticles at the Blood-Brain Barrier").

 

Literature arrow down

  1. NanoCare 2009, Final Scientific Report, Dechema e.V., Frankfurt a.Main. ISBN 978-3-89746-108-6. (PDF-Document, 19 MB).

 

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