Synthetically engineered nanozeolites can be taken up by different cell lines. However, the uptake mechanism strongly depends on the cell type and the surface charge of the nanomaterials.

 

Investigations in the laboratory have shown that, depending on the surface charge of the zeolite nanoparticles and the studied cell line (e.g. intestine, lung, phagocytes), the nanomaterials are taken up into the cells by different routes. In HeLa cells, modified nanozeolites enter the cells via active processes, depending on their surface charge and agglomeration state. Positively charged and specially coated zeolite nanoparticles show a high uptake rate in contrast to uncoated or negatively charged nanozeolites. However, the exact uptake mechanisms for the individual zeolite classes are still unclear [1-4].

Due to their porous structure, zeolites can also act as filters in biological fluids. On top of the particle surface a layer of proteins and other constituents of the surrounding fluid form depending on the nature of the particle surface. This process not only influences the agglomeration behaviour of the particles, but also their availability and subsequent uptake into the cells. [5].

 

The uptake of zeolite nanoparticles in cells depends strongly on the cell type, the surface charge and the respective protein or lipid layer on the particle surface.

 

 

Literatur arrow down

  1. Thomassen, LC et al. (2012), Nanotoxicology, 6(5): 472-485.
  2. Vilaca, N et al. (2013), Colloids Surf B Biointerfaces, 112 237-244.
  3. Bhattacharya, K et al. (2012), Toxicol Lett, 215(3): 151-160.
  4. Li, Z et al. (2013), Small, 9(9-10): 1809-1820.
  5. Laurent, S et al. (2013), Toxicology Research, 2(4): 270-279.

 

 

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